| Name | phage B30 lysin |
| Recommended Name ? | peptidoglycan endolysin |
| Systematic Name ? | peptidoglycan N-acetylmuramoylhydrolase |
| Alternative Name ? | GBS bacteriophage B30 lysin
1,4-N-acetylmuramidase mucopeptide glucohydrolase mucopeptide N-acetylmuramoylhydrolase muramidase N,O-diacetylmuramidase peptidoglycan N-acetylmuramoylhydrolase |
| Uniprot ID | Q8HA43 |
| General Mode of Action | Enzymatic cleavage of peptidoglycan which results in a rapid lysis of the bacterial cell. |
| phiBIOTICS Family ? | Lysozyme |
| Reaction ? | 1. Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins EC: 3.2.1.17 Corresponding Pfam domain: Glyco_hydro_25 Evidence: experimental (PubMed: 15256551) 2. Catalysis of the hydrolysis of the peptide bond between D-alanine and L-alanine in cell wall peptidoglycans EC: n/a Corresponding Pfam domain: CHAP Evidence: experimental (PubMed: 15256551) |
| Source Organism ? | Streptococcus phage B30 |
| Target Organism ? | Streptococcus agalactiae Streptococcus pyogenes |
| Note on Target | S. pyogenes is also known as Group A Streptococcus.S. agalactiae is also known as Group B Streptococcus.Phage B30 lysin also target Group C, E and G streptococci. |
| Disease ? | Acute glomerulonephritis (Group A Streptococcus) Acute rheumatic fever (Group A Streptococcus) Impetigo (Group A Streptococcus) Infective endocarditis (Group A Streptococcus) Neonatal sepsis (Group B Streptococcus) Pharyngitis (Group A Streptococcus) Postpartum infections (Group B Streptococcus) Rheumatic heart disease (Group A Streptococcus) Scarlet fever (Group A Streptococcus) |
| State ? | Tested |
| Reference ? | 15256551 |